Danazol can cause insulin resistance. Caution should be exercised when used with antidiabetic drugs. Capsules of 200 mg orange bottles of 100 NDC 0024-0305-06. Stir the mixture and drink all of it right away. The dosage requirements for continuous treatment of hereditary angioedema with Danazol capsules should be individualized on the basis of the clinical response of the patient. It is recommended that the patient be started on 200 mg, two or three times a day. After a favorable initial response is obtained in terms of prevention of episodes of edematous attacks, the proper continuing dosage should be determined by decreasing the dosage by 50% or less at intervals of one to three months or longer if frequency of attacks prior to treatment dictates. If an attack occurs, the daily dosage may be increased by up to 200 mg. During the dose adjusting phase, close monitoring of the patient's response is indicated, particularly if the patient has a history of airway involvement. cheap norethisterone from canada
Pearson K, Zimmerman HJ "Danazol and liver damage. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. How should I take danazol Danocrine?
Danocrine can induce ALA synthetase activity and hence porphyrin metabolism. Danazol may rarely cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness, or other discoloration of the skin, or a severe sunburn. Check with your doctor if this occurs. Miller EJ, Coleman FH "Pseudohypertestosteronemia during danazol therapy. A case report. Serious and sometimes fatal blood clots eg, stroke increased pressure in the head, and liver problems have been reported with the use of danazol. Notify your doctor immediately if you develop any of the following: calf or leg pain, redness, tenderness, or swelling; chest pain; fainting; headache; nausea or vomiting; shortness of breath; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; vision changes.
Tell your doctor if you become pregnant during treatment. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends. Gelatin, Silicon Dioxide, Sodium Lauryl Sulfate, Titanium Dioxide. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.
Diabetes patients - Danazol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Call your doctor at once if you have a serious side effect such as sudden numbness or weakness, problems with vision or speech, chest pain, sudden cough, or wheezing, swelling, rapid weight gain, feeling short of breath, ringing in your ears, dizziness, nausea, pain behind your eyes, stomach pain and loss of appetite, dark urine, or jaundice yellowing of the skin or eyes. If you are taking danazol for fibrocystic breast disease, you should have a breast exam before starting it. Contact your doctor right away if you experience new or persistent breast pain, tenderness, or lumps while taking danazol. Do not keep outdated medicine or medicine no longer needed. There are no data on the excretion of danazol into human milk. Breast-feeding is considered to be contraindicated by the manufacturer. Take this medication by mouth, usually twice daily or as directed by your doctor. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. In infrequent patients, symptoms of pain and tenderness may be severe enough to warrant treatment by suppression of ovarian function. Danazol Capsules USP are usually effective in decreasing nodularity, pain, and tenderness. It should be stressed to the patient that this treatment is not innocuous in that it involves considerable alterations of hormone levels and that recurrence of symptoms is very common after cessation of therapy.
This list is not complete and other drugs may interact with danazol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Castro-Magana M, Cheruvanky T, Collipp PJ, Ghavami-Maibodi Z, Angulo M, Stewart C "Transient adrenogenital syndrome due to exposure to danazol in utero. Sirolimus may also be used for purposes not listed in this medication guide. When these two medicines are taken together, your body may not process carbamazepine properly. Disclaimer: Every effort has been made to ensure that the information provided by Multum, Truven Health Analytics, Inc. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Danazol is used to treat endometriosis and fibrocystic breast disease. Danazol is also used to prevent attacks of angioedema in people with an inherited form of this disorder hereditary angioedema. If you are taking Rapamune oral liquid with a disposable syringe, you may store a loaded syringe in the carrying case provided. Keep the case at room temperature and use the medicine within 24 hours. Use a disposable syringe only once and then throw it away. Therapy should begin during menstruation. Do not use any other liquids to mix this medicine. Store sirolimus tablets at room temperature, away from heat, moisture, and light. Take danazol by mouth with or without food. The physician therefore should be alert to this possibility. Undiagnosed abnormal genital bleeding. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Drugs. azulfidine
Check with your doctor right away if you are a female and have a larger clitoris sexual organ deepening of your voice, or unusual hair growth after taking danazol. Your doctor may advise you to stop taking the medicine so these side effects do not get worse. Danazol has rarely caused very serious possibly fatal blood clots such as stroke liver disease, and increased pressure on the brain benign intracranial hypertension. Capsules of 50 mg orange and white bottles of 100 NDC 0024-0303-06. Moderate. These medicines may cause some risk when taken together. Renal side effects have included the retention of nitrogen, sodium, potassium, chloride, water and phosphorus, and decreased urinary excretion of calcium. Prolongation of prothrombin time occurs in patients stabilized on warfarin. Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea and vomiting, and visual disturbances. Patients with these symptoms should be screened for papilledema and, if present, the patients should be advised to discontinue danazol immediately and be referred to a neurologist for further diagnosis and care. Some MEDICINES MAY INTERACT with danazol. Danocrine, persistent amenorrhea has occasionally been reported. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60 to 90 days after discontinuation of therapy with Danazol, persistent amenorrhea has occasionally been reported. odim.info podophyllotoxin
You may need to have a negative pregnancy test before starting this treatment. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Capsules of 100 mg yellow bottles of 100 NDC 0024-0304-06. It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Resolution of pain and tenderness usually occurs following 1 to 3 months of therapy. Elimination of nodules often requires 4 to 6 months of uninterrupted therapy. Symptoms recur within one year in 50% of patients and therapy may be reinitiated if necessary. Administration of danazol has been reported to cause exacerbation of the manifestations of acute intermittent porphyria. To assure a female patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. clomipramine buy pharmacy otc
Sirolimus is used to prevent your body from rejecting a transplanted kidney. Sirolimus is sometimes used in a combination treatment with cyclosporine Neoral, Sandimmune and a steroid medicine such as prednisone. How should I take Danocrine danazol? Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. When the dose of Danocrine is doubled the increase in plasma levels is only about 35% to 40%. Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk. Enyeart JJ, Price WA "Bilateral sensorineural hearing loss from danazol therapy. A case report. Safety and effectiveness in pediatric patients have not been established. generic fosamax mail order store
In the treatment of endometriosis, Danocrine alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic. Complete resolution of endometrial lesions occurs in the majority of cases. Store danazol at room temperature, between 59 and 86 degrees F 15 and 30 degrees C in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep danazol out of the reach of children and away from pets. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. Avoid getting this medication on your skin, or around your nose and mouth. If it does get onto any of these areas, wash with soap and water. If this medicine gets into your eyes, rinse them with plain water. Avoid exposure to sunlight or tanning beds. Sirolimus may increase your risk of skin cancer. Wear protective clothing and use sunscreen SPF 30 or higher when you are outdoors. What should I discuss with my healthcare provider before taking danazol? Recent evidence suggests a direct inhibitory effect at gonadal sites and a binding of Danocrine to receptors of gonadal steroids at target organs. In addition, Danocrine has been shown to significantly decrease IgG, IgM and IgA levels, as well as phospholipid and IgG isotope autoantibodies in patients with endometriosis and associated elevations of autoantibodies, suggesting this could be another mechanism by which it facilitates regression of the disease. Use a barrier form of birth control such as a condom or diaphragm with spermicide. Hormonal contraception such as birth control pills, injections, implants, skin patches, and vaginal rings may not be effective enough to prevent pregnancy during your treatment with danazol. Should not be used in patients with these conditions. Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Do not mix this medicine with grapefruit juice. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus. Additionally a non-hormonal method of contraception should be used during therapy. If a patient becomes pregnant while taking danazol, administration of the drug should be discontinued and the patient should be apprised of the potential risk to the fetus. Exposure to danazol in utero may result in androgenic effects on the female fetus; reports of clitoral hypertrophy, labial fusion, urogenital sinus defect, vaginal atresia, and ambiguous genitalia have been received.
Clinical studies of Danazol did not include sufficient numbers of subjects aged 65 and over to determine the safety and effectiveness of Danazol in elderly patients. Mercaitis PA, Peaper RE, Schwartz PA "Effect of danazol on vocal pitch: a case study. Wentz AC "Adverse effects of danazol in pregnancy. Danazol may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use danazol with caution. An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Experience with long-term therapy with danazol is limited. Peliosis hepatis and benign hepatic adenoma have been observed with long-term use. Peliosis hepatis and hepatic adenoma may be silent until complicated by acute, potentially life-threatening intraabdominal hemorrhage. The physician therefore should be alert to this possibility. Attempts should be made to determine the lowest dose that will provide adequate protection. If the drug was begun at a time of exacerbation of hereditary angioneurotic edema due to trauma, stress or other cause, periodic attempts to decrease or withdraw therapy should be considered. Kingsbury AC "Danazol and fetal masculinization: a warning. buy glyburide china
Sirolimus can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly. Yaginuma T, Okamura T, Takeuchi T, Nishii O, Fujimori R "Preventive effect of traditional herbal medicine, shosaiko-to, on danazol-induced hepatic damage. The dosage requirements for continuous treatment of hereditary angioedema with Danocrine should be individualized on the basis of the clinical response of the patient. It is recommended that the patient be started on 200 mg, two or three times a day. After a favorable initial response is obtained in terms of prevention of episodes of edematous attacks, the proper continuing dosage should be determined by decreasing the dosage by 50% or less at intervals of one to three months or longer if frequency of attacks prior to treatment dictates. If an attack occurs, the daily dosage may be increased by up to 200 mg. During the dose adjusting phase, close monitoring of the patient's response is indicated, particularly if the patient has a history of airway involvement. Appropriate studies have not been performed on the relationship of age to the effects of danazol in the pediatric population. Safety and efficacy have not been established. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient. Danazol can increase the calcemic response to alpha calcidol in primary hypoparathyroidism. Cardiovascular side effects have included edema and congestive heart failure. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Peress MR, Kreutner AK, Mathur RS, Williamson HO "Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol. Follow your doctor's instructions about any restrictions on food, beverages, or activity. brand name of aprovel uk
It should not be given intravenously. Some medical conditions may interact with danazol. Do not take other medicines unless they have been discussed with your doctor. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Capsules of 200 mg orange bottles of 100 NDC 0024-0305-06. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Acne; changes in menstrual flow eg, spotting; changes in semen volume; decrease in breast size; excessively oily skin; flushing; hair loss; mild weight gain; sweating; vaginal itching or dryness; voice changes hoarseness, sore throat, change in pitch. Capsules of 200 mg orange bottles of 60 NDC 0024-0305-60. Use danazol regularly to get the most benefit. Try not to miss any doses. Get your prescription refilled before you run out of medicine completely. seroquel
What should I avoid while taking sirolimus Rapamune? If your symptoms do not improve or if they become worse, check with your doctor. In order for danazol to help you, it must be taken regularly for the full time of treatment as ordered by your doctor. What is the most important information I should know about danazol Danocrine? Experience with long-term therapy with Danazol is limited. Peliosis hepatis and benign hepatic adenoma have been observed with long-term use. Peliosis hepatis and hepatic adenoma may be silent until complicated by acute, potentially life-threatening intraabdominal hemorrhage. The physician therefore should be alert to this possibility. Attempts should be made to determine the lowest dose that will provide adequate protection. If the drug was begun at a time of exacerbation of hereditary angioneurotic edema due to trauma, stress or other cause, periodic attempts to decrease or withdraw therapy should be considered. Capsules of 200 mg orange bottles of 60 NDC 0024-0305-60. Danazol treatment may interfere with laboratory determinations of testosterone, androstenedione and dehydroepiandrosterone. Other metabolic events include a reduction in thyroid binding globulin and T4 with increased uptake of T3, but without disturbance of thyroid stimulating hormone or of free thyroxin index. What happens if I overdose Danocrine? Danazol may raise the plasma levels of cyclosporin and tacrolimus, leading to an increase of the renal toxicity of these drugs. Monitoring of systemic concentrations of these drugs and appropriate dose adjustments may be needed when used concomitantly with Danazol. In this event, treatment may be reinstated. warticon
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What is the most important information I should know about sirolimus Rapamune? Danocrine in the early 90's to treat endometriosis. I was supposed to take it for about 9 months to "simulate pregnancy" by stopping my menstrual cycle long enough to "heal". I could only do it for 3 months, because the side effects were awful. Danazol can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use if you are pregnant. This information should not be used to decide whether or not to take danazol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about danazol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to danazol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using danazol.
The information contained in the Truven Health Micromedex products as delivered by Drugs. Andriole GL, Brickman C, Lack EE, Sesterhenn IA, Javadpour N, Linehan WM, Frank MM "Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Hayden M, Buchanan N. Danazol-carbamazepine interaction.
Lipitor, Caduet fluvastatin Lescol lovastatin Mevacor, Altoprev, Advicor pitavastatin Livalo pravastatin Pravachol rosuvastatin Crestor or simvastatin Zocor, Simcor, Vytorin, Juvisync. Danazol is lipophilic and can partition into cell membranes, indicating the likelihood of distribution into deep tissue compartments. This may not be a complete list of all interactions that may occur. Ask your health care provider if danazol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Tell your doctor all medications and supplements you use.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. You must start taking this medicine while you are having your monthly period. If this occurs, the drug should be discontinued. Inactive Ingredients: Corn Starch, Lactose, Magnesium Stearate, Talc.